Endocrine Abstracts

Idiopathic hypogonadotropic hypogonadism (IHH) is a rare congenital disease caused by deficiency or action of gonadotropin-releasing hormone. While generally considered a long-life condition, IHH can be reversible in about 20-30% of cases, but mechanisms of reversibility are unknown. We report the case of a male with IHH who began treatment with low dose (20 mg/day) transdermal testosterone to induce pubertal development at age 18. Following the start of treatment, he experien...

Introduction: Most of pheochromocytomas (PCC) and paragangliomas (PGL) are sporadic. However, up to 40% of them have an inherited origin due to germline mutations in at least 15 known PCC/PGL genes, being the VHL and SDHx genes the ones most frequently affected. The fumarate hydratase (FH) is a Kreb’s cycle enzyme encoded by the FH gene.Its inactivating mutations increase intracellular levels of fumarate, leading to tissular pseudohypoxia and transcription of genes involv...

Introduction: Fine needle aspiration biopsy (FNAB) is the mainstay diagnostic procedure for evaluation of thyroid nodules, but it doesn’t permit to distinguish between benign and malignant follicular lesions (category IV in the Bethesda Cytopathology System). Some reports have suggested an association between increased serum levels of TSH and thyroid cancer. However, the specific relationship between TSH and malignancy has been scarcely studied in follicu...

Introduction: The thyroid-related quality-of-life patient-reported outcome ThyPRO questionnaire is the most widely used tool for measuring health-related quality of life (QoL) in patients with benign thyroid diseases. The aim of this study was to adapt and validate a Spanish version of the ThyPRO.Methods: The ThyPRO consists of 85 items, grouped in 13 scales and one single QoL item. Scales cover physical and mental symptoms, well-being and function, soci...